KEGG   Homo sapiens (human): 10055
Entry
10055             CDS       T01001                                 
Symbol
SAE1, AOS1, HSPC140, SUA1, UBLE1A
Name
(RefSeq) SUMO1 activating enzyme subunit 1
  KO
K10684  ubiquitin-like 1-activating enzyme E1 A [EC:6.2.1.45]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04120  Ubiquitin mediated proteolysis
Drug target
Subasumstat: D12268
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    10055 (SAE1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    10055 (SAE1)
Enzymes [BR:hsa01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.45  E1 ubiquitin-activating enzyme
     10055 (SAE1)
Ubiquitin system [BR:hsa04121]
 Ubiquitin-activating enzymes (E1)
  UBL-activating enzymes
   10055 (SAE1)
SSDB
Motif
Pfam: ThiF
Other DBs
NCBI-GeneID: 10055
NCBI-ProteinID: NP_005491
OMIM: 613294
HGNC: 30660
Ensembl: ENSG00000142230
UniProt: Q9UBE0
Structure
Position
19:47130835..47210636
AA seq 346 aa
MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK
VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA
PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
NT seq 1041 nt   +upstreamnt  +downstreamnt
atggtggagaaggaggaggctggcggcggcattagcgaggaggaggcggcacagtatgac
cggcagatccgcctgtggggactggaggcccagaaacggctgcgggcctctcgggtgctt
cttgtcggcttgaaaggacttggggctgaaattgccaagaatctcatcttggcaggagtg
aaaggactgaccatgctggatcacgaacaggtaactccagaagatcccggagctcagttc
ttgattcgtactgggtctgttggccgaaatagggctgaagcctctttggagcgagctcag
aatctcaaccccatggtggatgtgaaggtggacactgaggatatagagaagaaaccagag
tcatttttcactcaattcgatgctgtgtgtctgacttgctgctccagggatgtcatagtt
aaagttgaccagatctgtcacaaaaatagcatcaagttctttacaggagatgtttttggc
taccatggatacacatttgccaatctaggagagcatgagtttgtagaggagaaaactaaa
gttgccaaagttagccaaggagtagaagatgggcccgacaccaagagagcaaaacttgat
tcttctgagacaacgatggtcaaaaagaaggtggtcttctgccctgttaaagaagccctg
gaggtggactggagcagtgagaaagcaaaggctgctctgaagcgcacgacctccgactac
tttctccttcaagtgctcttaaagttccgtacagataaaggaagagatcccagttctgat
acatatgaggaagattctgagttgttgctccagatacgaaatgatgtgcttgactcactg
ggtattagtcctgacctgcttcctgaggactttgtcaggtactgcttctccgagatggcc
ccagtgtgtgcggtggttggagggattttggcacaggaaattgtgaaggccctgtctcag
cgggaccctcctcacaacaacttcttcttcttcgatggcatgaaggggaatgggattgtg
gagtgccttggccccaagtga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (15)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (48)   
   RefSeq(nuc) (4)   
   GenBank (22)   
   EMBL (22)   
3D Structure (9)   
   PDB (9)   
Protein domain (1)   
   Pfam (1)   
All databases (94)   

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